Potential Alport Biomarkers, Treatment Targets Identified in Stem Cell Analysis

Using stem cells derived from Alport syndrome (AS) patients to examine their genetic and protein profile, scientists identified three factors — microRNA-4775, ELV-like protein 1-A (ELAVL1), and epidermal growth factor receptor (EGFR) — as likely candidates in this genetic disease’s underlying mechanisms, and possible targets for treatments. The study “…

Correct Alport Diagnosis Crucial but Not Always Straightforward, Case Report Shows

A case report recently demonstrated that a correct diagnosis of Alport disease is crucial, but it may be difficult to distinguish from thin basement membrane disease — a similar kidney condition that doesn’t progress to kidney failure — and even biopsies can give inconclusive results. The study, “An Overlapping Case of Alport…